Hot trial hypertension

Felodipine was given as baseline therapy with the addition of other agents, according to a five-step regimen.

Findings: Diastolic blood pressure was reduced by The lowest incidence of major cardiovascular events occurred at a mean achieved diastolic blood pressure of Further reduction below these blood pressures was safe. Interpretation: Intensive lowering of blood pressure in patients with hypertension was associated with a low rate of cardiovascular events.

The HOT Study shows the benefits of lowering the diastolic blood pressure down to Acetylsalicylic acid significantly reduced major cardiovascular events with the greatest benefit seen in all myocardial infarction. If the target blood pressure still was not reached, a combination of felodipine, an ACE inhibitor and a beta blocker could be used, or hydrochlorothiazide could be added. The mean diastolic blood pressure from 6 months on showed a dramatic reduction.

The HOT investigators noted that there was poor separation between the three targets and that it was difficult to show significant differences between the three groups for major cardiovascular events and all MI. Although the aspirin group did not show an increased risk of cerebral bleeding, other bleeds gastrointestinal, nasal were approximately twice as common in the aspirin group.

The HOT study is the largest intervention hypertension trial to be conducted, involving more than 19, patients in 26 countries. Although it was difficult to distinguish between the three target blood pressure groups, the lowest rate for major cardiovascular events was found at a diastolic blood pressure of Blood Press ; Baseline characteristics 2.

Clinical Topics: Prevention, Statins, Hypertension. Description: Aspirin and diastolic BP reduction on major cardiovascular events in hypertension. Hypothesis: To assess the relationship of cardiovascular events to diastolic blood pressure, and the effect of low-dose aspirin in addition to anti-hypertensives.